I got this from Wiley-Blackwell today..
Quote:
The excerpt below is from a new "proof-of-principle" study, published in Epilepsia, which demonstrates that primary prevention in epilepsy is a realistic goal.
This is the first time that a treatment has been found which can suppress the development of epilepsy.
Epilepsy is a chronic disease characterized by recurrent unprovoked seizures. Present treatments are aimed at control of seizures, but do not cure the underlying disease (Duncan et al., 2006).
Genetic susceptibility plays an important role in many forms of epilepsy (Berkovic et al., 2006). With improved understanding of the human genome, the potential to predict epilepsy makes primary prevention a realistic goal (Collins, 1999). However, it is not known whether intervening at a critical stage of development can alter the course of epileptogenesis.
As a proof of-principle study, we sought to determine whether early treatment, prior to the development of epilepsy, would alter the course of epilepsy development in an animal model. This goal is in keeping with recently proposed "Benchmarks for epilepsy research" (http://www.ninds.nih.gov/).
Read the article online-early at:
http://www.blackwell-synergy.com/doi...7.2007.01458.x
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