I agree with Chemar. Believe me, I can relate to much of what you have said. I have had health issues that involve pain and fatigue. In addition, I have had to care for those in need. The two together are very draining for the body and soul. You might want to discuss the possibility of depression with a doctor. An antidepressant might be warranted. What about traditional therapy? I also believe in simple self care. Getting in some moderate exercise when you are able, eating healthfully and doing things you enjoy like listening to music or calling a friend. You don't have to spend inordinate amounts of time on these things, but be sure that you have your own "special time," to relax. In addition, like Chemar said, there are vitamins that might be of some assistance. The vitamin thread on this board is very active. Off the top of my head, the B vitamins, particularly B6 is known to help with depression as well as Fish Oil supplementation. Wishing you better days ahead.