Originally Posted by barb02

I had my 4th infusion today; I am premedicating with .25mg of benadryl and 2 tylenol. I had another reaction and had to receive an iv of benadryl. This time I experienced lower back spasms, extremely bad headache, cold chills, shakes, and up and down pulse and blood pressure. I was also coughing alot.
symptoms for the most part started after infusion so I had a complete one.

I am so frustrated and upset. I almost hit a car exiting the clinic parking garage. Neuro ordered bloodwork for liver (will have tomorrow)and discussed the melanoma issue with me (see dermatologist next week for mole scan). After reaction he said he wanted to talk to the drug manufacturers to see if they have any suggestions. I told him I want to continue on ty and he said, "we'll see." He did mention the possiblity of giving me an iv of benadryl prior to the infusion.

I had no problem with 1st infusion, had chest pains and tightness and shortness of breath with second and no problems with 3rd (premedicated for first time).