Hello! I recently joined and thought I'd say hello. I've had MS since 1997 - Ah! I can't believe its been that long - but at the same time i can. My main symptom right now is physical/mental fatigue and cognitive impairment. Does anyone know if anything can be done for the cognitive impairment? I have a Masters degree in Counseling Services but I don't have a job! I don't feel like I can focus or function. The frustrating thing is that all through college i had active lesions and physical symptoms - now...for the very first time i had NO lesions on my last MRI but I feel like so crummy and i have these cognitive symptoms. I'm on Tysabri and I know the studies have shown that tysabri is effective and obviously it is according to my last MRI - but my MRI is not showing on the outside. Anyone on tysabri or have these kind of symtoms. I'm so glad i found this site! Josie