I have been on Avonex since about June 1997. I had only one lesion back then and I still have only one lseion. I am not going to claim that the Avonex made the difference but I don't want to switch! When I started I had mild flu symptoms for about a month. Not the whole month but for a day after my shot. So I would take the shot on Friday nights. Now I don't have any flu symptoms. I have had a history of some really weird dreams the night of my shot and the Aleve that I take doens't seem to effect it. My family just knows that it was another Avonex night for me! We have come to laugh about a lot of what happens to your body with MS. My husband says I need to write a book about what I hear him say vs what he did say. I was an RN so needed no help in giving my shots but I did make sure someone else knew just in case I did come to a point in my MS hthat I couldn't give it. My husband was a medic in thr Navy.