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Old 03-11-2008, 06:48 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Post It is important...

It is really important to know if you are allergic to sulfa (sulfonamides).

Some food additives will cross react with this allergy..Sulfur dioxide (preserves fruits like raisins), and sodium bisulfite (in some foods and salad bars), can
cause headache, and asthma in sulfonamide allergic people.

If a patient with sulfa allergy is exposed to any sulfonamide drug, there is a potential for a severe reaction, called Stevens-Johnson syndrome, which may result in death if severe. There was a drug in the 70's called Kynex made by Lederle labs, which was a once every 24 sulfa. People who developed allergies to it while it remained in the body for several days after stopping, became very ill, some lost their hearing and some died. It was taken off the market. Bactrim and Septra are 12 hr duration tablets, and that is a long time too.
Some reactions are confined to the skin only (severe rashes), and others may include asthma, and shock.

Levaquin is a fluoroquinolone. I am not aware of cross sensitivity of this family of drugs to sulfonamides.
here is a site that gives details on this drug:
http://www.drugs.com/mmx/levofloxacin.html
Here are the ingredients of the tablets:
Quote:
Tablets: 250 mg: Each modified rectangular, film-coated, terra cotta pink tablet contains: levofloxacin 250 mg. Nonmedicinal ingredients: crospovidone, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, synthetic red iron oxide and titanium dioxide. Bottles of 50.

500 mg: Each modified rectangular, film-coated, peach tablet contains: levofloxacin 500 mg. Nonmedicinal ingredients: crospovidone, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, synthetic red and yellow oxides and titanium dioxide. Bottles of 50.
from http://www.rxmed.com/b.main/b2.pharm.../LEVAQUIN.html

I have seen patients react to povidone ingredients in tablets, if they are allergic to organic iodine. This is very uncommon, however, and only the smaller 250mg tablet has it.

Not all reactions to drugs are allergic in nature. Some are side effects, unpleasant, but not life threatening. A true allergy may be sudden, and overwhelming, but it gives warnings as a rule first. Itching (hives), redness of the skin,shortness of breath, etc, are the typical warning signs of allergy.

Nausea, headache, aches and pains, are not typically found in allergic responses. Levaquin and other fluoroquinolone drugs enter the brain and cause excitability there. They can cause seizures (Floxin was the worst in this regard), confusion, mental apathy, which is worse in elderly than in younger patients. This is not an allergy, it is side effects and intolerance. So it is important to understand the differences.
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Last edited by mrsD; 03-11-2008 at 02:21 PM.
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