Ok I did it! Had my first Tysabri infusion today. They ran it over two hours then observed me for one hour after. No problemo so far! I premedicated with Ibuprofen and Bendaryl a little stronger than the usually recommended Clariten but I am extremely med sensitive so thought it was a wise choice. The only problem is I am a bit tired but hey thats normal right? Here's keeping the fingers crossed it keeps going as smoothly!!