what a co-incidence...i am just wondering about the dyskinesia (mild) and dystonia after two years of stalevo administration. Initially, stalevo works quite well for me with prolonged life span of "on" time. However, in the last 6 months, the 3rd dosage of stalevo comes with it mounting dystonia. My doctor suggested me to cut down to two dosages of stalevo 100 and replace the 3rd dosage of stalevo with sinemet CR. I am still trying whether the new regime gives me sustained "on" time without the unwanted side effects.

My perception is that PD medicine or more correctly our brain has a very mysterious behavior (tricky response) to long term medication, chemicals that worked well before may not live up its promise in the long run. Sometimes, it may turn out quite messy. Excessive usage (though sometimes unavoidable) tends to shorten the life span of certain drugs.

LING