--the usual figures I've seen is that R-lipoic is considered sox to ten times more potent per milligram than alpha lipoic.

Mrs. D's reaction is farily typical. I myself went from 600mg/day alpha lipoic to 100mg/day of R-lipoic, but even at my size (I'm about 205 pounds) I found that to be a little strong--my blood sugar was going down too low and I felt more lethargic; lipoic is not only a potent antioxidant, but has strong blood glucose lowering properties, and as I do not have a diabetic blood sugar level to start . . .

I've now been taking one 100mg/R-lipoic every other day and that seems to keep me more even; I may order 50mg capsules and take one each day and see how that works.