I am going to agree with LizaJane. I went through all the testing. In my case there are issues with the L5/S1 and I have a fractured coccyx...C3 to be exact and the tip of it. ALL of this nerve damage has caused a lot of problems. So, Premarin Cream, pelvic floor PT and every now and then an injection into the coccyx. There is not much more I can do other than the above. Of course it is different than having IC. But you are right...the Premarin Cream may make alot of difference. It did for me. The PT, internal work, helped with the muscle spasms and the coccyx injections take the inflammation down. All of it has worked well. Actually, the Premain Cream if it is not a neuropathy issue, will help with the burning pain if you have that symptom as well. And I believe your doc is taking the right course. LizaJane is right...you would be amazed at how this all comes together and/or connects. It doesn't have to necessarily be neuropathy or even IC. Because I thought the same thing at one time and that wasn't it at all. It is just mainly nerve damage from my lumbar/sacral area causing a lot of this. It gets very involved and very complicated. I am thankful I had a great Reproductive Endocrinologist and Urogynecologist along with my spinal PM to help me get it ALL figured out. And very thankful for a PT specializing in this.