Wow - the autoinject is what I use (and my husband too) - the needle doesn't go in quite as far as it does manually even when set to 10 - I guess it is an individual thing - for me the manual hurts and the auto doesn't - and no site reaction other then some redness and swelling that goes away in half an hour - don't know if you know that there's a way to adjust the needle depth on the autoinject and I found that if I press hard into the area I'm injecting with the autoinject - I do get a bruise - so I hold it against my skin but don't use too much force - my husband's been doing it for me and he's been holding the front of autoinject flush with my skin and applying very little downward pressure - so far so good -