Barb,

I know two people who have tested positive for antibodies. One was tested after 8 infusions (found to be positive) and is now on another therapy. One tested positive after being taken off Tysabri when it was pulled from the market. When it was returned, he went back on and started having major systemic reactions. He is in hope that the antibodies were transient and that he will be able to return to the therapy. Only time will tell in his case. Those are the only two people I have heard from who have had antibodies, out of the hundreds I have had contact with who started and reported on their Tysabri experience. 99.9% of the people I have had continuing contact with are still on Tysabri and continue to report on decreased relapses and progression.

I have not been tested for antibodies because I have had no adverse events, and my 6 month MRI showed vast improvement. I would be tested if I was having reactions after 6 months or if in the first 6 months I had adverse events that continued to worsen. Your results will come back and answer your questions.

As always, Tysabri is not for everyone. It's like every other drug. What works for one may not work for another. It is not a failure, it's an intolerance. We all have them, for one thing or another , regardless of how much we try to be accepting or accomodating or hope they will help or that the adversity will go away.

I wish you nothing but good results with Tysabri. Only you and your doctor can say when it's time to move on. The norm is 6 months, but if it's bad for someone I would be the last one to say stick with it. It's your choice and life is too short to feel bad!

PLease let us know how your tests turn out.