Acyclovir (Zovirax) does not have any published papers involving nutrient depletions yet.

Tetracycline however, is a huge depleter, esp for long term use:

Vitamin B1
B2
B3
B6
B12
Biotin
Inositol
Calcium
Magnesium
Iron
Vitamin K (due to the death of beneficial organisms in the bowel)
And Bifidus organisms normally that live in the bowel.

Birth control typically affects:
Folic acid
B2
B6
B12
zinc
magnesium
Vit C
But this varies from product to product.

Typically a high potency multivitamin can cover most bases.
Magnesium
Calcium may have to be taken separately.

Prednisone affects the above,
with the addition of Vit D, Selenium, and potassium.
Once you end prednisone, you should slowly go back to
normal, if you are eating well, and have a varied diet.

Signs of low B6 status are numbness tingling in the extremities.
Signs of low zinc are frequent infections/sore throat (including acne)
Signs of low calcium may be leg cramps or numbness/tingling of the face/mouth.
Signs of low magnesium may be leg cramps or other muscle twitching/cramping.
Signs of low Vit C show up quickly as bleeding gums.
Low B12 over time may show up as neuropathies, excess fatigue.(people can store B12 for up
to 5 years in the liver, so B12 may not show up as deficient until alot of time has passed.)