I was on Cymbalta for 6 months this year. In the last year too I have truied neurontin,lyrica,elavil,tramadol,and vicodin. Anyhow for me cymbalta and I was on 60 did nothing. When I went off it we weaned and I had a head ache but sometimes I get that anyway. Other then that not much else. Mrs D no one ever checked my liver while on it. Just when I had random blood work. I always before the cymbalta had high liver enzymes but two months ago they were finally normal for the first time in years. Good luck in your choice and I encourage you to tell your doc your fears.