Calcium channels are typically blocked by magnesium ions.
These papers do not address unbalanced calcium intake vs proper magnesium supplements.
NMDA receptors which are pain mediated and calcium driven, are blocked by magnesium.
It is not a simple thing..to only point to calcium.. you cannot live without this, and if you do not consume some, your bones will leach it out, since there is a heirarchy in calcium utilization. The body will take the calcium from bone to run the heart.
Quote:
We don't really know, though we do know that genes predispose people to the illness, and that stress can trigger an episode. One possibility is there is an overabundance of the excitatory neurotransmitter glutamate in the synapse (the space between two neurons) due to cortisol, which is secreted as part of the "flight or fight" reaction to stress. The glia - the "other" brain cell - is thought to clear excess glutamate from the synapse, but bipolar patients have a shortage of glia. Glutamate in turn allows calcium to flow through an ion channel penetrating the cell membrane and into the neuron and activates calcium-dependent enzymes inside.
There are other ion channels that may be overstimulated in response to various neurotransmitters. In addition, researchers are also looking at the neurotransmitter dopamine, with is involved in pleasure and reward. There is also some evidence that vitamin or mineral deficiencies may play a role. In all likelihood, several processes are occurring at once, and not necessarily the same ones individual to individual.
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from
http://www.mcmanweb.com/bpfaq1.htm
Much of the new research is in regards to methylation and bipolar.
http://www.riken.go.jp/engn/r-world/...ics/index.html
By hitting the cause here, at the root, the cascade that follows may be blocked. This is genetically driven, and rather new, and complex as well.
And there are drugs coming in trials now, called ampakines, to address this
glutamate issue.
http://en.wikipedia.org/wiki/Ampakines
Given the negative impact of excessive glutamate consumption ..esp monosodium glutamate, anyone with a neuro issue should avoid MSG in
processed foods. This is an artificial glutamate and our bodies cannot
handle it well. MSG is a huge ingredient, in almost everything. Avoid Avoid!
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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