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Old 10-13-2006, 08:16 PM
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ZucchiniFlower ZucchiniFlower is offline
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Join Date: Sep 2006
Posts: 782
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Can't answer your question yet, Paula. But this is interesting:

J Neurol Neurosurg Psychiatry 1998;64:573-576 ( May )

Continuous subcutaneous waking day apomorphine in the long term treatment of levodopa induced interdose dyskinesias in Parkinson's disease
A Colzi, K Turner, A J Lees

Received 24 July 1997 and in revised form 22 October 1997; Accepted 23 October 1997

OBJECTIVES---To determine whether continous waking day dopaminergic stimulation with the dopamine agonist apomorphine can reduce levodopa induced dyskinesias in Parkinson's disease
METHODS---19 patients with severe unpredictable refractory motor fluctuations and functionally disabling levodopa induced dyskinesias were treated with continuous subcutaneoius apomorphine monotherapy for a minimum duration of 2.7 years


RESULTS---A mean 65% reduction in dyskinetic severity and a mean 85% reduction in frequency and duration occurred. On discontinuing levodopa a concomitant reduction in off period time was also seen (35% of waking day "off" reduced to 10%)


CONCLUSION---Continuous waking day dopaminergic stimulation with apomorphine reset the threshold for dyskinesias and led to a pronounced reduction in their frequency.

Apomorphine should be considered as a less invasive alternative to pallidotomy or deep cerebral stimulation in controlling levodopa induced interdose dose dyskinesias.
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