I am currently taking gabapentin, ultram, celexa, cyclobenzaprine, and a few other meds, and I had no idea that I would become irregular. Just as you stated, twice a day was normal 4 me, and I take my multi vit along with omega 3's daily. I have sinced greatly increased my dietary fiber (I thought just eating normal fruits and vegs would do the trick) I am still having issues, but if you decide to do the hot water, I suggest putting a large amount of pure lemon juice. It helps to get things moving. Taking so many meds have taken a toll on my life, and I hope that I do not have to turn to disability. I have herniated discs in my neck, per.neuropathy in both legs, and fibromyalgia. Getting enough fluids helps. I have given thought about getting an internal cleansing done, which I think may get me back to normal. Hope this helps! Good luck!