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Environmental Factors
Furthermore, a possible relationship between Sjögren's syndrome and Helicobacter pylori infection has been suspected. In both these conditions there are increased risks of developing mucosa-associated lymphoid tissue lymphoma (Isaacson and Spencer 1987; Parsonnet et al, 1994). It has been suggested that infection with H. pylori might trigger a widespread clonal B-cell disorder in Sjögren's syndrome (De Vita et al, 1996). Studies on antibodies against H. pylori in Sjögren's syndrome though have given conflicting results as to whether seroreactivity is elevated or not (Showji et al, 1996; Aragona et al, 1999; Theander et al, 2001). However, improvement of sicca symptoms has been indicated after eradication treatment of H. pylori (Figura et al, 1994)
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Signs & Symptoms
A wide range of neurological disorders has been reported, the peripheral nervous system being most frequently affected (neuropathy) but occasionally also CNS.
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Claire