My speculation as to why more people aren't using Metanx is that many of the savvy supplementers realize one can get what's in Metanx over the counter for the most part (except for, possibly, the methylfolate--as Mrs. D has said, I believe, that is now enitrely prescription).

Moreover, many of us would rather take our B12 apart form other vitamins for maximal absoprtion.

Nevertheless, if one has good insurance, and the co-pay and overall cost is less than that of ordering the Metanx components seperately through one of the on-line purveyors, it might be a good choice.