Originally Posted by RLSmi

I have been diagnosed for 7 years, but my PD symptoms are still pretty mild. One of the things I do experience when my meds are running low (about the closest thing I have to an "off") is what I call my "shuffle step", more correctly, festination. This is most likely to happen early in the morning before meds take hold, or late in the afternoon when I forget my p.m. meds. It always responds to sinemet meds.
I take one-half a 25/100 sinemet generic at the same time as a 50/200 CR sinemet generic twice a day. If I am attentive to when I take them; first dose upon rising, second dose at 4-5 p.m.; I can usually avoid "Mr. Shuffles".
I also take 100mg amantadine in the a.m., and 300 mg CoQ10 three times a day (with meals). I am also a strong believer in dextromethorphan, of which I take 4-5 mg every night at bedtime. This is in the form of a pediatric over-the-counter cough medicine, Pedia Care, which contains 7.5 mg of the drug per 5 cc (one teaspoon). I take between one-half to two-thirds of a teaspoon of the cough syrup each night. I think it has something to do with the very slow progression (if any) that I am experiencing. It may be providing significant neuroprotection. I know others on this forum who are also taking either dextromethorphan at this low dose, or naltrexone, a similar drug. I am not recommending that anyone take either one, since it is my (our) own "white rat" adventure.
Can you share what meds, if any, you presently take?
Robert