Thanks for this information. My hubby takes Methadone and is doing well with it. It is true that one must be careful when starting this med. My hubby almost OD'd on it in the beginning because it "appeared" to not be working at first so the nurse in charge of the methadone dosage up'd the med not realizing the danger. He became disorientated and extremely high one day and I called the doctor who immediately stopped his dosage to a much lower dose. The doctor knew what had happened and how methadone takes time to get into the system. Needless to say, that nurse wasn't in charge anymore.