This drug does affect mito functions, so yes, I'd say try it.
Not inexpensive, but may help.
NOW brand at iherb is pretty reasonable.
Quote:
Cell Biochem Funct. 1989 Apr;7(2):129-34.Links
Methotrexate: studies on cellular metabolism. II--Effects on mitochondrial oxidative metabolism and ion transport.
Yamamoto N, Lopes LC, Campello AP, Klüppel ML.
Departamento de Bioquímica Universidade Federal do Paraná, Brasil.
Effects of methotrexate (MTX) on mitochondrial oxidative metabolism and ion transport were studied. MTX decreases the membrane potential (delta psi) upon energization of the mitochondrial membrane by NAD+-linked substrates and decreases the amplitude and velocity of swelling induced by glutamate and alpha-ketoglutarate. MTX also has an inhibitory effect on the activities of the oxidation enzymes of NAD+-linked substrates without interfering with the oxidation systems of FAD-linked substrates. The effects of MTX could be interpreted as a consequence of a decrease in the ionic conductivity of the mitochondrial inner membrane.
PMID: 2766470 [PubMed - indexed for MEDLINE]
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Yes, the dose would similar. Some people take really high doses of carnitine.
Most people respond to 1-2 grams a day given in divided doses (there is limited absorption from the GI tract). I found one reference that said in doses over 4 grams a day there may be suppression of thyroid hormone, so that should be tested. I am not aware of thyroid problems with CoQ-10.
The HIV community typically uses very high doses of carnitine.
This is a pretty good monograph, giving details
http://www.catie.ca/supple-e.nsf/07d...3!OpenDocument
This monograph does not mention any thyroid issues:
http://lpi.oregonstate.edu/infocente...ine/index.html
The thyroid interaction seems to be related to the fact that carnitine is used in hyperthyroid people to prevent bone loss.
Some extrapolate this to effects on normal thyroid actions, but others say it doesn't work that way. So getting tested is a good
idea.
example:
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
and this which is the opposite:
http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum
(saying carnitine is low in hypothyroid patients)
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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