Cherie, I have some good info on the accrual of disability that proceeds independently of the lesions seen on MRI - and especially the difference in the process of CNS damage that occurs in SPMS and PPMS. I referred to it above when I was talking about the direct degeneration of axons. That is where the newer info in MS is focusing and where the analysis of Inflammation/myelin/lesions/disability breaks down. It answers a lot of the points you brought up.

It also shows that I am not good at keeping my word. I have to break form the 'puter now. I'm in a relapse (or an exasperation as we say at my house) and I can no longer contorl my right hand.

President and Founder of the support group for people who talk too much:

ON-AND-ON ANON

Quix