First off, as you can probably guess by my user name I am a pilot.

Secondly, the cabin pressure inside commerical airplanes is kept at a comfortable altitude so it shouldn't bother you. Having said that, it would depend on whether or not any pressure bothers your TN.

I have MS and sometimes pressure bothers me. Do you have problems when you drive up a hill? Or when you take an elevator up to the top of a tall building? It would be the same type of pressure change. Or even when the barometer changes from a high pressure to a low pressure.

The 2 1/2 hour flight would not be a significant period of time for most people but people with TN are not most people! If you are that concerned, I would ask your doctor for something to help you with the pain that you could take just before the trip to help you relax, maybe a xanax or valium to relax.

Have a great flight and a good time in NY!