I agree with Nancy in regard to the biopsy. It won't likely show any villi damage (due to gluten), but it may show other problems.
I would ask yourself how you are feeling. While not everyone is back to 100% at six months, if you are feeling really good and have no intention of returning to eating gluten~ you might just want to skip the biopsy. If you are still having GI problems/symptoms in December, it might be worthwhile to have the scope to rule out any other problems. There is a chance it might show signs of healing celiac disease at that point, but with negative bloodwork and six months of gluten free diet, the chance would be very slight.
I'd leave it on the books for now, and wait until December to cancel (if you decide to cancel) based upon how you feel then.
Maybe your skin biopsy will come back positive, and then you will have a diagnosis!
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how come the bipopsy they take from your intestine isn't tested for Iga antibodies?
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You know, I think that Dr. Hadjivassiliou is looking for that in patients with gluten ataxia who do not show villous atrophy, and they are finding intestinal antibody deposits in otherwise normal villi tissue. Still, after six months gf, even if they looked..they might not find it.
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OBJECTIVE: To investigate the presence of autoantibody deposition against type 2 tissue transglutaminase (TG2; a reliable marker of the whole spectrum of gluten sensitivity) in the jejunal tissue and brain of patients with gluten ataxia and in control subjects. METHODS: The authors evaluated jejunal biopsy samples from nine patients with gluten ataxia and seven patients with other causes of ataxia for the presence of TG2-related immunoglobulin deposits using double-color immunofluorescence. Autopsy brain tissue from one patient with gluten ataxia and one neurologically intact brain were also studied. RESULTS: IgA deposition on jejunal TG2 was found in the jejunal tissue of all patients with gluten ataxia and in none of the controls. The intestinal IgA deposition pattern was similar to that seen in patients with overt and latent celiac disease and in those with dermatitis herpetiformis. Widespread IgA deposition around vessels was found in the brain of the patient with gluten ataxia but not the control brain. The deposition was most pronounced in the cerebellum, pons, and medulla. CONCLUSIONS: Anti-tissue transglutaminase IgA antibodies are present in the gut and brain of patients with gluten ataxia with or without an enteropathy in a similar fashion to patients with celiac disease, latent celiac disease, and dermatitis herpetiformis but not in ataxia control subjects. This finding strengthens the contention that gluten ataxia is immune mediated and belongs to the same spectrum of gluten sensitivity as celiac disease and dermatitis herpetiformis.
PMID: 16476935
Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia.
PMID: 16476935 Feb 2006
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Cara