Sassy, so sorry to hear that you are having problems! At least the doc wants to see you and is not putting you off.

I was on Avonex and went to Rebif. Love rebif! Avonex I had the horrible flu symptoms after the shot. Rebif is not so bad. I have done so well on rebif also. I am in a flare now but it is my first major one since I started rebif over a year ago. I have had no depression sx with either, so I can't help you out there. I only have the flu, achy body side affects.

I was also told NO to tysabri because I had melanoma last year, so that is most likely a no for you. If doc is trying to sell you on it I would say no because of your previous history with melanoma.

Good luck tomorrow! Keep us posted!