Rosebud, Bonnie, my father-in-law has already started his weaning from Sinemet. Today is the third day. So far so good. I will report the details in a couple of days when the trend is clear.

Yesterday, they went to a seminar. Lo and behold, the doctor giving the seminar was his neuro. After the seminar, he told the neuro that after taking the meds regularly, his OFF time just has become so much worse. The neuro said that it's probably because his brain couldn't get use to the fluctuation of dopamine levels. When he asked if he could wean from Sinement, the doctor said that once you were on it, it's very difficult to get off. To us, the only logical explanation is that the introduction of dopamine into the brain discourages the endogenous formation of it.

Same goes for agonist, the doctor said. Once you are on, it's hard to get off. Weaning from it will make you extremely uncomfortable, he said.

We really wished he had told us before we took the med regularly.

So after the seminar, he is firmer than ever to wean from the med.

Has any of you started too?