poisons administered into the bowel could kill you very quickly, so I believe
you should not go that way at all -the gut is where we get our nutrtion from,when our food is broken down - if anything sub-lingual may be better?


link -
http://www.indiana.edu/~engs/rbook/drug.html
Route of Administration

A very important factor influencing the reaction of drugs in the body is the method by which it is administered.

Oral. Perhaps the most common way of taking drugs is orally (by mouth). This is the most convenient method for most people to take drugs and permits digestion to modify drugs that might be too powerful or too fast acting if administered directly into the bloodstream. Once in the stomach, some drugs, such as alcohol, can go directly into the bloodstream without further digestion. However, most drugs are absorbed into the circulatory system along with glucose, amino acids, minerals, and vitamins, after being passed into the large or small intestine. Drugs that are soluble in lipids (fats), such as barbiturates, vitamins D and E, and THC, the active principle in marijuana, tend to remain longer in the body. Water-soluble drugs , such as vitamin C, alcohol, and antibiotics used for urinary tract infections, tends to be excreted rapidly by the kidneys. The major detoxification organ of the body is the liver, which removes chemicals and toxins from the blood and renders them harmless and easier to excrete. The elimination of most substances takes place in the urinary tract and the Annal canal. However, excretion of some drugs can also take place through the respiratory system and skin.

Inhalation. Some drugs, such as anesthetics, nicotine in cigarettes, solvents, marijuana, and drugs for treating lung disorders, are inhaled through the mouth. Cocaine and some forms of amphetamine are usually inhaled through the nose, where it is absorbed through the mucous membrane in the nostrils. Because the lungs have large beds of capillaries, inhaled chemicals are capable of crossing the membranes to enter the blood fairly rapidly. A problem with inhaling drugs such as tobacco, marijuana, and cocaine, is that they irritate the mucous membrane lining found in the respiratory tract.

Injection. Injection is a common way of administering drugs, particularly in a hospital or medical setting. Injection is also used on the street with opiates and sometimes with cocaine and heroin. Drugs taken by injection can be intravenously, intramuscularly, or subcutaneously administered. In intravenous injections, the drug can go directly into the circulatory system and act immediately. Drugs such as heparin (reduces clotting of blood), some antibiotics, glucose and salt solutions, and drugs given to cancer and heart attack patients and in emergency situations are often given intravenously. Intravenous injections can be dangerous because of impurities found in many street drugs, errors in dosage, bubbles in the syringe, and infection from puncturing the skin and vein. Intramuscular injections are given in the large muscles of the buttocks, upper leg, or arm and are used for drugs that need to be fairly rapidly absorbed into the circulatory system, such as antibiotics and narcotic-analgesics. Subcutaneous injections are given right beneath the skin and are used for drugs that are rendered inactive by the digestive system, such as heparin, and insulin and for drugs that need to be absorbed more slowly into the circulatory system.

Rectally or Vaginally. The rectum will absorb many drugs. Suppositories containing sleeping aids, such as chloral hydrate, tranquilizers, such as Thyroxin(R), and antinausea medication, such as Compazine(R), are commonly given to elderly or extremely sick people who are unable to swallow medications. Vaginal medication is usually used to cure local infections caused by various organisms. Cutaneously. Some drugs and substances can be absorbed directly through the skin. Various "sore ligament" preparations would be an example of these, along with cortisone in the treatment of poison ivy. The absorption, of course, is usually very slow.

PSYCHOLOGICAL EFFECTS OF DRUGS

The psychological setting or frame of mind is important in the effect of many drugs, particularly with psychotropics. Psychological effects are also important for other medications and treatments and often result in cures or symptomatic relief when no drugs has actually been given.