I was on A for 2 years and have now been on R for 3 years. I never had more than a day of side effects. Nothing that motrin couldn't handle. 800 mg was what was recommended to me. I took it before the shot, and then again the next morning. I might need one more late afternoon, but not usually.

I found that drinking a lot of water and exercising the next morning made the side effects much more manageable and they felt less severe.