I have severe GERD and take Nexium. It works OK as long as I don't go off my diet too much. I've been on every med possible including Protonix. I've had issues since I gave birth to my second son. The last endoscopy showed severe redness and some erosion. Nexium is the last med to try and I am sure in time that too will stop working after some time. After that I think surgery is the only option unless a new pill comes out.

I hope you find some relief soon. I feel for you. I used to go through so many tests including upper GI, barium enema and endoscopy. It wasn't until the endoscopy that they found the GERD, post ulcerative scars and deformation at the duodenum.