Foot prints, PLEASE have your sister seek another opinion. One who has a bit of experience in MS. MS is difficult to diagnose anyhow, and if your neuro is conservative, or not very familiar, it may go undiagnosed for no good reason.

Lesions can be caused by many things, even nutritional deficiencies and migraines. The fact that it DID NOT highlight with GAD simply means the lesion is old, or "not active."

Here is a quick simple formula for diagnosing MS (please do a lot more research, this is just a quicky). 2 isolated events, at different times (otherwise if it is just one event, it is called a "clinical isolated event"). MRI lesions, positive LP. Bloodwork to rule out Lyme and lupus. If all that criteria is met, a diagnosis can be given.

Your sister may not want an LP, but it can give a quick confimatory diagnosis (quick is actually 2 weeks). It really is painless other than the little sting on numbing meds they give (the LP HA, if you get it is he!! though, I did have that). BUT, knowing is so worth is.

Please have her follow up with someone familiar with MS, preferable a GOOD specialist (there are some who say they are specialists, but they are not).

Good luck to you both. Tell her to push for some answers!!! Even if it is not MS, something is WRONG, and they need to find out what!!