Wow, that's a hefty oral dose. Usually prednisone is taken in the am when your adrenal gland is most active.But with that size oral dose, dividing it might be easier on your tummy. I hope your neuro gave you a script for your tummy, like a proton pump inhibitor.

Sending hugs your way, hoping you start to feel better. I am amazed that you are going to go to work. I think you should take some time off and be good to yourself!!