Below is a recent ABC News video on LDN from the Low Dose Naltrexone website. The LDN website believes that low doses of naltrexone increase endorphins in the brain thus enhancing the immune system. There do not seem to be any valid tests done in humans yet to show this to be true. Although, a recent clinical trial done in Milan with MS patients and LDN has yet to be made public so maybe that will settle the matter. I think the work done by Dr. Hong, Head of the Pharmacology Group of the NIH shows more convincing reasons on how LDN seems to work. They have produced many papers over the past eight years showing that opioid receptor antagonists like LDN and dextromethorphan, DM, can greatly reduce neuro-inflammation in PD induced rodents.
http://www.lowdosenaltrexone.org/index.htm

Maybe the way to deal with PD is to try and stop neuro-inflammation. Naltrexone and dextromethorphan are cheap, safe and in the case of DM easily available. I have been taking LDN now for 47 months plus 600mg of Q10. My overall combo of sinemet and mirapex has not increased over that time. But, maybe like Robert, I am still early onset and the other shoe has yet to drop.
Ashley
http://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Abstract
http://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Abstract