I've been on Trileptal since diagnosed PPMS in Dec. 2007. Am now up to 600 mg. twice daily and I don't know if it's doing anything.

I was on Neurontin with it, and that gave me intestinal problems when I got to the higher levels so I got off of it.

Then I was put on Lyrica and am up to 150 mg. twice daily. No difference.

I just asked for Cymbalta and will begin at 15 mg. at bedtime.

All this time, I'm continuing on the Trileptal cause the doctor wants to only change one thing at a time to see if it works...which makes sense.

I'm just being hopeful, but it seems as if nothing wants to help my tough pins and needles in my feet, all day and night. But I'm not giving up until I have to!

Good Luck to you!
Kippy