Thread: Tysabri Talk
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Old 10-23-2006, 04:19 PM
msladyinca's Avatar
msladyinca msladyinca is offline
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Join Date: Oct 2006
Location: So. Calif.
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15 yr Member
msladyinca msladyinca is offline
Junior Member
msladyinca's Avatar
 
Join Date: Oct 2006
Location: So. Calif.
Posts: 11
15 yr Member
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Wow Sally, not even close but, thank you for your post...
Quote:
There may be no lesions on MRI, with many symptoms and great disability, and then there may be many lesions with no disability.
I did not say "are not" silent lesions forming, I said "does not mean there won't be", as anything is possible with MS, i.e., nothing is "concrete"....you are actually talking "apples and oranges"; when I was going by what Ewizabeth stated:
Quote:
I'm on Copaxone and not doing so great.
which "implies" she is having more lesions causing more symptoms (lesions are the scarring that is interrupting the nerve signal due to myelin loss/damage", thus the disability.
http://www.nationalmssociety.org/What%20is%20MS.asp

Quote:
But, if Tysabri does lower the risk of exacerbations, that has to be a good thing. It does have a (what did XO say) 10% better efficacy rate at reducing exacerbations, than the CRABS...
Not sure if you are terribly misinformed or what Sally, but please, let me enlighten you re: Tysabri....there is no if when it comes to it's proven 68% superior efficacy...here is the New England Journal of Medicine's (where some of the most highly respected unbiased medical opinions in the worldopined: "Results Natalizumab reduced the risk of sustained progression of disability by 42 percent over two years (hazard ratio, 0.58; 95 percent confidence interval, 0.43 to 0.77; P<0.001)....Natalizumab reduced the rate of clinical relapse at one year by 68 percent (P<0.001) and led to an 83 percent reduction in the accumulation of new or enlarging hyperintense lesions, as detected by T2-weighted magnetic resonance imaging (MRI), over two years (mean numbers of lesions, 1.9 with natalizumab and 11.0 with placebo; P<0.001). There were 92 percent fewer lesions (as detected by gadolinium-enhanced MRI) in the natalizumab group than in the placebo group at both one and two years (P<0.001)." Volume 354:899-910 March 2, 2006 Number 9

Furthermore...
Quote:
The Jury's still out on it being better than fried rice, though, since, just like the crabs, the majority of PWMS will not respond favorably to Tysabri
Wrong again Sally, see the PROVEN DATA recently released: TYSABRI® Demonstrates Improvement in Cognitive Function (http://www.elan.com/News/full.asp?ID=910099); TYSABRI® Demonstrate Significant Reduction in Steroid Use and Hospitalizations (http://www.elan.com/News/full.asp?ID=913012; TYSABRI® Has Sustained Effect on Relapse Rate for up to Three Years (http://www.elan.com/News/full.asp?ID=910437); TYSABRI® Improves Quality of Life (http://www.elan.com/News/full.asp?ID=840112).

Kinda difficult to argue with proven data, Sally..plus I happen to like "fried rice" alot, and I'd venture a guess that alot of others do too!

Best wishes to you also.

Lauren
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Last edited by msladyinca; 10-23-2006 at 04:27 PM.
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