Yes, weight loss is a very common side effect of Wellbutrin. In fact, a lot of people use it 'off label' as an adjunct for weight loss. Wellbutrin is known for its benefits for curbing certain cravings such as carbohydrates and nicotine. Wellbutrin AKA Zyban, is currently used for those who wish to quit smoking and is quite effective for some. A lot of insurance companies are starting to jump on board and pay for it for that use. It is definitely not just for depression anymore.