I am curious as to what you meant by the changes in the study once Schering came on board. Can you describe specifically how you were prior to the surgery, what was most dificult for you? what has been the biggest improvement. Where you adversely affected by your meds (frequent dyskinesia) I could not find a doseage for my sinemet that gave me relief without having dyskinesia. Now that I have had DBS I take the sinemet but don't have them.