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Junior Member
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Join Date: Aug 2006
Posts: 48
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Junior Member
Join Date: Aug 2006
Posts: 48
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Quote:
Originally Posted by kingrex
I'd be interested in seeing a link to that timetable and to the assertion that he had not been immunosuppressed for 8 months prior to being started on Tysabri. I've never read that anywhere.
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Quote:
The second fatal PML case reported in the NEJM occurred in a 60-year-old Belgian man who had received five doses of Tysabri for Crohn's disease as part of a clinical trial, wrote Paul Rutgeerts, M.D., Ph.D., and colleagues at the University of Leuven Hospitals in Leuven, Belgium.
The patient died five months after reporting to the emergency room with severe confusion and disorientation. Although he was originally thought to have died from an astrocytoma, the investigators took another look at the serum samples and brain lesion tissues taken at biopsy after hearing about two other cases of PML in patients on Tysabri.
The investigators found evidence of the JC polyomavirus in blood samples taken three months after the patient had started on an open-label trial of Tysabri, but before he had exhibited symptoms. The patient had previously taken the immunosuppressant Imuran (azathioprine), but had discontinued it eight months before admission to the hospital.
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http://www.medpagetoday.com/Neurolog...erosis/tb/1170
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