the problem is with our main medicine / it has been deemed (the Gold systemof the PD drugs)
the Sinemet now known as Levodopa/Carbidopa...
the mirapex - is worse for me - I will never take it again... and some do fine
they think -yet it causes low blood pressure fuzzy thinking and
who knows what else, and now it is being given to the Restless Leg syndrome patients of which some are young teenagers?

http://www.scribd.com/search?query=mirapex

http://www.mirapex.com/?sc=MIRMIWEBSEM0507_001 [RLS ad]

http://www.mirapex.com/pd/Controller.jpf [PD ad]

here's the QUICK PDF for PD patients -
http://www.mirapex.com/pd/resources/...th_Mirapex.pdf

I typed in "gambling" to see if it was contained in the PDF - says - no?

here is the link for the pharmacist paperwork usually taken out of original box -to put the pills in prescription bottles with very little info on them:
depends upon the quality of the pharmacy?
I used to be a pharmacy technician...
http://bidocs.boehringer-ingelheim.c...ex/Mirapex.pdf

page 10 -
Renal
Since pramipexole(generic name for Mirapex) -added by Tena for clarity

is eliminated through the kidneys, caution should be exercised when prescribing Mirapex® (pramipexole dihydrochloride) tablets to patients with renal insufficiency (see DOSAGE AND ADMINISTRATION).
Dyskinesia
MIRAPEX tablets may potentiate the dopaminergic side effects of levodopa and may cause or exacerbate preexisting dyskinesia. Decreasing the dose of levodopa may ameliorate this side effect.
Retinal Pathology in Albino Rats
Pathologic changes (degeneration and loss of photoreceptor cells) were observed in the retina of albino rats in the 2-year carcinogenicity study. While retinal degeneration was not diagnosed in pigmented rats treated for 2 years, a thinning in the outer nuclear layer of the retina was slightly greater in rats given drug compared with controls. Evaluation of the retinas of albino mice, monkeys, and minipigs did not reveal similar changes. The potential significance of this effect in humans has not been established, but cannot be disregarded because disruption of a mechanism that is universally present in vertebrates (i.e., disk shedding) may be involved (see ANIMAL TOXICOLOGY).
Events Reported with Dopaminergic Therapy
Although the events enumerated below may not have been reported in association with the use of pramipexole in its development program, they are associated with the use of other dopaminergic drugs. The expected incidence of these events, however, is so low that even if pramipexole caused these events at rates similar to those attributable to other dopaminergic therapies, it would be unlikely that even a single case would have occurred in a cohort of the size exposed to pramipexole in studies to date.
Withdrawal-Emergent Hyperpyrexia and Confusion
Although not reported with pramipexole in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in antiparkinsonian therapy.
Fibrotic Complications
Although not reported with pramipexole in the clinical development program, cases of retroperitoneal fibrosis, pulmonary infiltrates, pleural effusion, and pleural thickening, pericarditis, and cardiac valvulopathy have been reported in some patients treated with ergot-derived dopaminergic agents. While these complications may resolve when the drug is discontinued, complete resolution does not always occur.
p -11

page 12 -
Impulse Control/Compulsive Behaviors
Cases of pathological gambling, hypersexuality, and compulsive eating (including binge eating) have been reported in patients treated with dopamine agonist therapy, including pramipexole therapy. As described in the literature, such behaviors are generally reversible upon dose reduction or treatment discontinuation.
continue reading page 12!

okay read page 23 of the above PDF

Other Adverse Events Observed During Phase 2 and 3 Clinical Trials
MIRAPEX tablets have been administered to 1620 Parkinson’s disease patients and to 889 RLS patients in Phase 2 and 3 clinical trials. During these trials, all adverse events were recorded by the clinical investigators using terminology of their own choosing; similar types of events were grouped into a smaller number of standardized categories using MedDRA dictionary terminology. These categories are used in the listing below.

Adverse events which are not listed above but occurred on at least two occasions (one occasion if the event was serious) in the 2509 individuals exposed to MIRAPEX tablets are listed below. The reported events below are included without regard to determination of a causal relationship to MIRAPEX tablets.
Blood and lymphatic system disorders: anemia, iron deficiency anemia, leukocytosis, leukopenia, lymphadenitis, lymphadenopathy, thrombocythaemia, thrombocytopenia
Cardiac disorders: angina pectoris, arrhythmia supraventricular, atrial fibrillation, atrioventricular block first degree, atrioventricular block second degree, bradycardia, bundle branch block, cardiac arrest, cardiac failure, cardiac failure congestive, cardiomegaly, coronary artery occlusion, cyanosis, extrasystoles, left ventricular failure, myocardial infarction, nodal arrhythmia, sinus arrhythmia, sinus bradycardia, sinus tachycardia, supraventricular extrasystoles, supraventricular tachycardia, tachycardia, ventricular fibrillation, ventricular extrasystoles, ventricular hypertrophy
Congenital, familial and genetic disorders: atrial septal defect, congenital foot malformation, spine malformation
p. 23