This is a very dangerous drug... you could have a hidden, non-symptomatic
bleed from it.
http://www.rxlist.com/cgi/generic/indometh.htm
Most doctors are unaware of long term NSAID use and poor healing.
It is usually after the 4 week mark that this begins. Since this involves
cox-2 cytokines, and this concept is complex, it is not generally known.
(remember Vioxx? -- even with warnings, it was misunderstood).
example:
http://ajs.sagepub.com/cgi/content/abstract/29/6/801
Quote:
|
Celecoxib-treated/injured ligaments were found to have a 32% lower load to failure than untreated/injured ligaments. The results of this study do not support use of cyclooxygenase-2 specific inhibitors in the treatment of ligament injuries.
|
and this:
http://www.springerlink.com/content/72w112h1mq218451/
I had a CE (continuing ed class) where this was brought up in relation to osteoarthritis treatment long term with NSAIDs.
People on long term NSAIDs should try and use a proton pump inhibitor daily.
There can be some protection afforded this way, but not 100%. Some studies show benefit in preventing GI bleeds.
Indomethacin is the highest bleeding causing NSAID in the whole family.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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