Another example of a serious aspect of PD that could be eased by diet. Within the power of each of us if we figure out the program to follow.

1: Biogerontology. 2004;5(6):365-73.

Glucose, glycation and aging.

Suji G, Sivakami S.

Department of Life Sciences, University of Mumbai, Santa Cruz (E), Mumbai 400
098, India.

Glycation, a deleterious form of post-translational modification of
macromolecules has been linked to diseases such as diabetes, cataract,
Alzheimer's, dialysis related amyloidosis (DRA), atherosclerosis and Parkinson's
as well as physiological aging. This review attempts to summarize the data on
glycation in relation to its chemistry, role in macromolecular damage and
disease, dietary sources and its intervention. Macromolecular damage and
biochemical changes that occur in aging and age-related disorders point to the
process of glycation as the common event in all of them. This is supported by
the fact that several age-related diseases show symptoms manifested by
hyperglycemia. Free radical mediated oxidative stress is also known to arise
from hyperglycemia. There is evidence to indicate that controlling hyperglycemia
by antidiabetic biguanides prolongs life span in experimental animals. Caloric
restriction, which appears to prolong life span by bringing about mild
hypoglycemia and increased insulin sensitivity further strengthens the idea that
glucose via glycation is the primary damaging molecule.

PMID: 15609100 [PubMed - indexed for MEDLINE]