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Member
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Join Date: Jan 2008
Location: Maryland outside WASH DC
Posts: 258
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Member
Join Date: Jan 2008
Location: Maryland outside WASH DC
Posts: 258
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The benefit in reducing MMP-9s is enormous. They make the hole in the BBB Blood Brain Barrier and cut up myelin. I discussed this in my recent Avonex posting.
They do not mentuion MS in this abstract probably because it was done in 2002 and the MS MMP-9 connection was not published in detail until 2001.
jackD
Quote:
1: QJM 2002 Dec;95(12):787-796
Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR
genotype: mechanisms for inflammatory damage in chronic disorders?
Timms PM, Mannan N, Hitman GA, Noonan K, Mills PG, Syndercombe-Court D, Aganna
E, Price CP, Boucher(2) BJ.
Departments of. Clinical Biochemistry, Diabetes and Metabolic Medicine and.
Haematology, Barts and The London, Queen Mary's School of Medicine and
Dentistry, University of London and. Department of Cardiology, 'Barts and The
London' NHS Trust, London, UK.
BACKGROUND:Vitamin-D deficiency and vitamin-D receptor genotype (VDR) are risk
factors for several disorders with inflammatory components, including coronary
heart disease (CHD) and diabetes, though the mechanisms involved are unclear.
Aim: To examine the hypothesis that vitamin D status modulates the matrix
metalloproteinase (MMP) system in a population with a high prevalence of vitamin
D deficiency, a situation affecting susceptibility to CHD and diabetes.
DESIGN:
Prospective cross-sectional, interventional and embedded studies.
METHODS:
Circulating MMP2,9, the inhibitor TIMP-1 and C-reactive protein (CRP) were
measured during studies of vitamin-D deficiency as a risk factor for type 2
diabetes and CHD in 171 healthy British Bangladeshi adults, free of known
diabetes or major illness. Vitamin D status, VDR genotype, body-build, blood
pressure, lipid and insulin profiles, glucose tolerance, fibrinogen, PAI-1,
folate and homocysteine were measured. Vitamin-D-deficient subjects were
re-assessed after 1 years' supplementation. MMP, TIMP-1 and CRP levels were
measured in 41 subjects halfway through 5-year follow-up. Independent
determinants of circulating concentrations of MMP9, TIMP-1 and CRP were assessed
by multiple regression analysis.
 RESULTS: Vitamin D status was the sole
determinant of circulating MMP9 (inversely) and an independent determinant of
CRP (inversely). Determinants of TIMP-1 were MMP9, systolic blood-pressure
(directly) and VDR genotype (TaqI).  Significant reductions in MMP9 (-68%),
TIMP-1 (-38%) and CRP (-23%) concentrations followed vitamin-D supplementation.
DISCUSSION: Vitamin-D insufficiency is associated with increased circulating
MMP2,9 and CRP, correctable by supplementation. This finding provides a possible
mechanism for tissue damage in chronic inflammatory conditions, including and diabetes.
PMID: 12454321 [PubMed - as supplied by publisher]
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Last edited by Chemar; 06-20-2008 at 04:37 PM.
Reason: adding correct quote tags
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