Fiona, Thank you for the information and references. The book in the link from my last posting is a compilation of all the materials presented at a conference on Ibocaine in 1999 at the NYU med school. I have a friend at the medical school library looking for a copy for me. I understand Pharma does not want to find out if this natural plant has utility--wonder if contacts to MJF foundation or the PDF would be fruitful? If this substance truly increases GDNF without requiring neurosurgery--just taking a pill--what a product!!!! madelyn