I have always liked "The Simpsons", but lately it's gotten sort of tired and hackneyed. In my opinion.

I do enjoy "Family Guy". The local CW station runs repeats every evening for an hour. All the characters are enjoyable. Peter, Lois, Stewie, Brian, Quagmire, etc.

"American Dad" is okay. I think Seth MacFarlane has his hands in both "Family Guy" and "American Dad".

"King Of the Hill" appeals to me because I've been to Austin quite a few times and can see how some Austinites act like the characters in the cartoon!

I can't really pick a favorite out of all these. I enjoy them all.