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Member
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Join Date: Jan 2008
Location: Maryland outside WASH DC
Posts: 258
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Member
Join Date: Jan 2008
Location: Maryland outside WASH DC
Posts: 258
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idebenone - NGF
I also take some IDEBENONE to get some extra NGF production in my brain. It is a bit expensive and you need to take 2 caps daily.
jackD
p.s. It a modified form of CQ-10 and is somewhat difficult to find in stores. I hear the rats love the stuff. I can now make it thru the water maze in a flash.
Quote:
1: Naunyn Schmiedebergs Arch Pharmacol. 1994 Apr;349(4):401-7.
Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats.
Nitta A, Murakami Y, Furukawa Y, Kawatsura W, Hayashi K, Yamada K, Hasegawa T, Nabeshima T.
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Nerve growth factor plays an important role in the survival and maintenance of cholinergic neurons in the central neuronal system. In senile dementia of the Alzheimer type, learning and memory are impaired by the loss of neurons in the magnocellular cholinergic neuronal system.
It is therefore, of interest to investigate the role of nerve growth factor in this degenerative disorder.
 Since nerve growth factor does not cross the blood-brain barrier and is easily metabolized by peptidases when administered peripherally, it can be used for medical treatment only when directly injected into the brain.
 We demonstrate here that the oral administration of idebenone, a potent in vitro nerve growth factors synthesis stimulator, induced an increase in nerve growth factor protein and mRNA, and in choline acetyltransferase activity, in basal forebrain lesioned rats, but not in intact rats.
Idebenone also ameliorated the behavioral deficits in habituation, water maze, and passive avoidance tasks in these animals.
These results suggest that idebenone stimulated nerve growth factor synthesis in vivo and ameliorates the behavioral deficits which were accompanied with the recovery of the reduced choline acetyltransferase activity in the basal forebrain-lesioned rats.
PMID: 8058112 [PubMed - indexed for MEDLINE]
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Quote:
1: Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):27-32.Links
[Noben (idebenone) in the treatment of dementia and memory impairment without dementia][Article in Russian]
[No authors listed]
Noben (idebenone) was administered in dosage 120 mg during 6 months to 35 patients, aged from 60 to 86 years, with dementia, Alzheimer's type and mixed type, and with memory disturbances which did not reach the level of dementia. The assessment of patient's state before and after treatment was based on the results of somatic, neurological and psychiatric examination as well as neuropsychological testing and using of psychometrical and other scales. The significant improvement on the MMSE scale was found in patients with mild and moderate dementia.
The improvement of daily activity was observed in 27% of patients. The neuropsychological study revealed the improvement of short-term and delayed memory and attention, speech functions, the performance on kinesthetic, spatial and dynamic praxis tests, visual-spatial gnosis, reasoning and writing.
The positive therapeutic effect assessed by the CGI scale was observed in 37% of patients, the stable state--in 48%.
PMID: 18454094 [PubMed - in process]
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Last edited by jackD; 06-25-2008 at 10:56 AM.
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