Interesting to see how NGF and the Vit Ks work together to protect and enhance neuron outgrowth.
jackD
Quote:
Neurosci Lett. 2002 Apr 19;323(1):9-12.
Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells.
Tsang CK, Kamei Y.
Marine and Highland Bioscience Center, Saga University, 152-1 Shonan-cho, Karatsu, 847-0021, Saga, Japan.
The nerve growth factor (NGF)-potentiating effect of K vitamins on PC12D cells was investigated.
Treatment of PC12D cells with vitamin K(1) or K(2) in the presence of NGF significantly enhanced the proportion of neurite-bearing cells and acetylcholinesterase activity compared with NGF treatment alone.
The K vitamins-enhanced neurite outgrowth on PC12D cells was completely blocked by a protein kinase A (PKA) inhibitor or mitogen-activated protein kinase (MAPK) kinase inhibitor PD98059, whereas a protein kinase C inhibitor chelerythrine chloride did not significantly inhibit the enhancing effect of the K vitamins.
These results suggest that the K vitamins enhance neurite outgrowth via the activation of PKA and MAPK-mediated signaling pathways in PC12D cells.
PMID: 11911978 [PubMed - indexed for MEDLINE]
|