Yes all at once. This version of benfotiamine is fat soluble.
So some stays in the body and is not washed out as quickly as soluble thiamine.

I think there must be a loading dose issue. I started it for the burning I was having in my feet. Sometimes depending on what I ate that day (it seems cumilative) I get flaming, other days, little if any. Last summer the burning was very severe.

So I gauged my dosing based on my feet.(not the hands/arms).

But I do notice my arms don't fall asleep/numb anymore at night. And I don't need my wrist braces anymore. My wedding ring is not so tight either. (I wear a wide gold band which is a good signal for edema for me).

I have learned how to protect my hands, hold them so they are straight during the day etc. And so far luckily I have avoided surgery.

My son plays the bass, and he is having some problems too.
They are much worse for him if he eats gluten. So he went gluten free for a year or so. He has fallen back on old ways lately-- says the GF life is so hard on him financially-- but I don't hear much complaint yet about the hands. He is almost 27 yrs old.