Thread: High Drug Level
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Old 10-27-2006, 09:10 AM
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mrsD mrsD is offline
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb suggestions...

There are two major reasons for a sudden blood level change.

1) a change in hepatic functions (liver)-- due to damage, infection etc.

2) something has happened to your dosage form..the company who makes it
made a mistake, and that defective product was released, and you are using it.

Diamox can cause problems with primidone-- are you using the Sequels?
Quote:
DIAMOX modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteo-malacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy. By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone
So since the Diamox does the "reverse", perhaps, the Diamox is defective?
Before it might have been reducing your levels, and now there has been a change and it is not working that way? Also Diamox is capable of changing liver function and you don't mention liver tests. Did you have them?

http://www.rxlist.com/cgi/generic4/diamox_ad.htm

There seems to be a marked increase in drug company manufacturing errors, in the past 10 yrs. Some well known brand name companies have had issues...
Schering and GSK especially.

Some doctors titrate up with Keppra, starting slowly. This would be an option for you if you decide to try it.
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Last edited by mrsD; 10-31-2006 at 10:40 AM. Reason: fixing spelling
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