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Member
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Join Date: Jan 2008
Location: Maryland outside WASH DC
Posts: 258
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Member
Join Date: Jan 2008
Location: Maryland outside WASH DC
Posts: 258
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ANA can be elevated in MS also.
jackD
Quote:
1: Neurology. 1995 Feb;45(2):384-5.Links
Comment in:
Neurology. 1995 Dec;45(12):2299-300; author reply 2300-1.
Neurology. 1995 Dec;45(12):2299-300;author reply 2300-1.
Frequency of anti-nuclear antibodies in multiple sclerosis.Barned S, Goodman AD, Mattson DH.
Department of Neurology, University of Rochester Medical Center, NY.
We found anti-nuclear antibodies (ANA) in 26.7% of 150 relapsing-remitting and in 30.4% of 23 chronic progressive definite multiple sclerosis (MS) patients by retrospective chart review.
 These patients did not have systemic lupus erythematosus.
Since ANA are not pathogenically relevant in MS, they are false-positive, and likely reflect systemic immune dysregulation in MS.
PMID: 7854544 [PubMed - indexed for MEDLINE]
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Quote:
1: Mult Scler. 1999 Apr;5(2):121-5. Links
Autoimmunity in multiple sclerosis: study of a wide spectrum of autoantibodies.Spadaro M, Amendolea MA, Mazzucconi MG, Fantozzi R, Di Lello R, Zangari P, Masala G.
Institute of Nervous and Mental Diseases, University of Rome La Sapienza, Italy.
The aim of this study was to assess the frequency of organ- and nonorgan-specific autoantibodies in MS patients and evaluate whether the presence of autoantibodies is an indicator of disease activity and/or a prognosis factor.
One hundred and five definite MS patients in different stages and with different course and 75 blood donors were tested for the autoantibodies TgA, TMA/TPO-A, PCA, ANA, aCl, SMA, AMA and ANCA.
All patients were screened for the LAC. Autoantibodies to at least one autoantigen were found in 66.6% MS patients and in 13.3% controls (P < 0.001). The frequency of TgA, TMA/TPO-A, ANA, aCl and SMA was statistically higher in patients than in controls. Circulating ANCAs were found in seven MS, a never reported finding.
An early onset of MS (< 20 years) was associated with a lower autoantibody frequency (P < 0.01) Primary and secondary progressive MS had a higher antibody frequency than relapsing-remitting (P < 0.05) or benign (P < 0.001) MS.
Up to 86% of patients were autoantibody-positive during the acute stage, but only 30% of them remained positive during the remission stage (P < 0.001).
A generalised immune dysregulation occurs in MS patients, mostly during the acute stages and in the progressive courses, involving activation of both autoreactive Th1-cells (mainly linked to CNS lesions) and B-cells via Th2 cells.
PMID: 10335521 [PubMed - indexed for MEDLINE]
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Last edited by jackD; 07-04-2008 at 11:31 PM.
Reason: Irodit cait sppell
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