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Wisest Elder Ever
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
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more ZINC papers...
Zinc and acne:
Quote:
Dermatology. 2001;203(2):135-40. Related Articles, Links
Click here to read
Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris.
Dreno B, Moyse D, Alirezai M, Amblard P, Auffret N, Beylot C, Bodokh I, Chivot M, Daniel F, Humbert P, Meynadier J, Poli F; Acne Research and Study Group.
Department of Dermatology, CHU Nantes, France.
BACKGROUND: In addition to tetracyclines, zinc may constitute an alternative treatment in inflammatory lesions of acne. OBJECTIVE: To evaluate the place of zinc gluconate in relation to antibiotics in the treatment of acne vulgaris. METHODS: Zinc was compared to minocycline in a multicenter randomized double-blind trial. 332 patients received either 30 mg elemental zinc or 100 mg minocycline over 3 months. The primary endpoint was defined as the percentage of the clinical success rate on day 90 (i.e. more than 2/3 decrease in inflammatory lesions, i.e. papules and pustules). RESULTS: This clinical success rate was 31.2% for zinc and 63.4% for minocycline. Minocycline nevertheless showed a 9% superiority in action at 1 month and one of 17% at 3 months, with respect to the mean change in lesion count. Regarding safety, the majority of the adverse effects of zinc gluconate and of minocycline concerned the gastrointestinal system and were moderate (5 dropouts with zinc gluconate and 4 with minocycline). CONCLUSION: Minocycline and zinc gluconate are both effective in the treatment of inflammatory acne, but minocycline has a superior effect evaluated to be 17% in our study. Copyright 2001 S. Karger AG, Basel
Publication Types:
* Clinical Trial
* Multicenter Study
* Randomized Controlled Trial
PMID: 11586012 [PubMed - indexed for MEDLINE]
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Minocycline upsets the bacteria in the GI tract and can lead to Candidiasis..something very hard to eradicate. Yeast overgrowth, then, can be avoided by trying zinc first. There will be fewer side effects of nausea, if zinc monomethionine is used.
Zinc is used in long term care facilities for wound repair:
Quote:
1: Int Wound J. 2004 Jun;1(2):150-1.Click here to read Links
Wound problems due to zinc deficiency.
* Patel GK,
* Harding KG.
Department of Dermatology and Wound Healing Research Unit, University of Wales College of Medicine, Heath Park, Cardiff, UK. patelgk@cf.ac.uk
Zinc deficiency, though uncommon, can occasionally present in current medical practice. A 4.5-year-old boy with previous gastrointestinal surgery presented with diarrhoea, disinterest and dermatitis affecting the face and perineum. The clinical diagnosis was confirmed by the presence of a low serum zinc level. Administration of parenteral zinc led to rapid improvement in diarrhoea, demeanor and dermatitis. Further surgery was then undertaken, surgery had been postponed until normalisation of zinc levels due the association between zinc deficiency and poor postoperative wound healing.
PMID: 16722889 [PubMed - indexed for MEDLINE]
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It is an ingredient in Arginaid (by Resource) and in various ointments used
for healing.
Many of the acne products are mixtures of antioxidants and zinc. That is because zinc does not work ALONE. Vits A C E and the mineral selenium are also included.
Here is a very new paper on zinc and airway maintenance:
Quote:
1: Curr Drug Targets. 2006 May;7(5):607-627.Click here to read Links
Zinc and its specific transporters as potential targets in airway disease.
* Murgia C,
* Lang CJ,
* Truong-Tran AQ,
* Grosser D,
* Jayaram L,
* Ruffin RE,
* Perozzi G,
* Zalewski PD.
Department of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia.
The dietary group IIb metal zinc (Zn) plays essential housekeeping roles in cellular metabolism and gene expression. It regulates a number of cellular processes including mitosis, apoptosis, secretion and signal transduction as well as critical events in physiological processes as diverse as insulin release, T cell cytokine production, wound healing, vision and neurotransmission. Critical to these processes are the mechanisms that regulate Zn homeostasis in cells and tissues. The proteins that control Zn uptake and compartmentalization are rapidly being identified and characterized. Recently, the first images of sub-cellular pools of Zn in airway epithelium have been obtained. This review discusses what we currently know about Zn in the airways, both in the normal and inflamed states, and then considers how we might target Zn metabolism by developing strategies to monitor and manipulate airway Zn levels in airway disease.
PMID: 16719771 [PubMed - indexed for MEDLINE]
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Here is a paper on improving healing following hip replacement:
Quote:
1: Wound Repair Regen. 2006 Mar-Apr;14(2):119-22.Click here to read Links
Low serum zinc level as a predictive factor of delayed wound healing in total hip replacement.
* Zorrilla P,
* Gomez LA,
* Salido JA,
* Silva A,
* Lopez-Alonso A.
Department of Orthopaedic Surgery and Traumatology, Complejo Hospitalario Ciudad Real, Ciudad Real, Spain. pedrozorrillaribot@hotmail.com
Delayed wound healing after total arthroplasty puts the patient at risk for superficial and deep infection, with substantial economic and social consequences. The objective of this study was to assess serum zinc levels as a tool for predicting such a delay in patients with primary osteoarthritis or osteoarthritis secondary to avascular necrosis. We conducted a prospective study of 80 total hip arthroplasties, analyzing possible correlations between delayed healing and serum zinc, nutritional parameters, and other demographic and epidemiological variables. The predictive value of preoperative serum zinc levels and lymphocyte counts was confirmed; thus, an arthroplasty procedure could be timed to minimize risk.
PMID: 16630099 [PubMed - indexed for MEDLINE]
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I work often in long term care providers (nursing homes and hospice) so I was very impressed by this new article:
Quote:
1: Nutrition. 2006 Jan;22(1):82-8.Click here to read Links
Nutritional status and food intake in nine patients with chronic low-limb ulcers and pressure ulcers: importance of oral supplements.
* Raffoul W,
* Far MS,
* Cayeux MC,
* Berger MM.
Chirurgie Plastique et Reconstructive, CHUV, Lausanne, Switzerland.
OBJECTIVES: Chronic low-limb ulcers and pressure ulcers are a serious and costly issue. Malnutrition is a risk factor. Searching for intervention strategies in elderly patients referred for surgical closure of their ulcers, the trial aimed at investigating the micronutrient status, determining the food intake of such patients, and the role of oral liquid supplements. METHODS: Observational cohort study in 9 patients, starting 5 days prior to surgery until day 10 after surgery. Variables: body mass index (BMI), food intake assessed using standardized meals (energy target 25 kcal/kg/day). Oral liquid supplements were provided between meals. Laboratory: blood count, plasma proteins, antioxidant status, vitamins, Fe, Se, and Zn. RESULTS: The patients were aged 71+/-10 y (mean+/-SD), with a BMI of 23.3+/-3.3. Baseline blood samples showed anemia and strong inflammation in 4 patients: albumin, retinol, and selenium were low; iron and zinc were very low. Food intake was largely variable and covered only about 76% (31-95%) of energy requirements. Breakfast provided 225+/-110, lunch 570+/-215, and dinner 405+/-150 kcal. Supplements were willingly consumed covering 35+/-12% of energy target. While vitamin supply was adequate, selenium and zinc requirements were not met. CONCLUSIONS: Most patients with chronic skin ulcers suffered micronutrient status alterations, and borderline malnutrition. Meals did not cover energy requirements, while oral supplements covered basic micronutrient requirements and compensated for insufficient oral energy and protein intakes, justifying their use in hospitalized elderly patients.
PMID: 16455446 [PubMed - indexed for MEDLINE]
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Used in this country typically is Arginaid brand.
example:
Quote:
1: Clin Nutr. 2005 Dec;24(6):979-87. Epub 2005 Nov 15.Click here to read Links
Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial.
* Desneves KJ,
* Todorovic BE,
* Cassar A,
* Crowe TC.
Department of Nutrition and Dietetics, Austin Health, Studley Road, Heidelberg 3084, and School of Exercise and Nutrition Sciences, Deakin University, Burwood, Australia.
BACKGROUND & AIMS: Nutrients putatively implicated in pressure ulcer healing were evaluated in a clinical setting. METHODS: Sixteen inpatients with a stage 2, 3 or 4 pressure ulcer randomised to receive daily a standard hospital diet; a standard diet plus two high-protein/energy supplements; or a standard diet plus two high-protein/energy supplements containing additional arginine (9 g), vitamin C (500 mg) and zinc (30 mg). Nutritional status measurements (dietary, anthropometric and biochemical) and pressure ulcer size and severity (by PUSH tool; Pressure Ulcer Scale for Healing; 0=completely healed, 17=greatest severity) were measured weekly for 3 weeks. RESULTS: Patients' age and BMI ranges were 37-92 years and 16.4-28.1 k g/m2) respectively. Baseline PUSH scores were similar between groups (8.7+/-0.5). Only patients receiving additional arginine, vitamin C and zinc demonstrated a clinically significant improvement in pressure ulcer healing (9.4+/-1.2 vs. 2.6+/-0.6; baseline and week 3, respectively; P<0.01). All patient groups presented with low serum albumin and zinc and elevated C-reactive protein. There were no significant changes in biochemical markers, oral dietary intake or weight in any group. CONCLUSIONS: In this small set of patients, supplementary arginine, vitamin C and zinc significantly improved the rate of pressure ulcer healing. The results need to be confirmed in a larger study.
PMID: 16297506 [PubMed - indexed for MEDLINE]
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and this general paper:
Quote:
1: Dermatol Surg. 2005 Jul;31(7 Pt 2):837-47; discussion 847. Links
Zinc and skin health: overview of physiology and pharmacology.
* Schwartz JR,
* Marsh RG,
* Draelos ZD.
Beauty Care Product Development, The Procter & Gamble Company, Cincinnati, Ohio 45251, USA. Schwarts.jr2@pg.com
BACKGROUND: Zinc is known to have a critical role in overall human physiology, which likely explains many of its therapeutic uses for the last several thousand years. The specific roles zinc plays in skin health and function are less widely known yet are likely just as critical based on the manifestations of dietary zinc deprivation, which include moderate to severe dermatitis. OBJECTIVE: To provide a critical review of the scientific literature as to the physiologic importance of zinc to skin, the biochemical basis for these effects, and pharmacologic aspects of zinc therapeutics. RESULTS AND CONCLUSIONS: Skin is in a continual state of renewal, placing a high demand on zinc-based enzymes and proteins that direct this process. The importance of zinc physiologically is especially evident in studies of wound healing and inflammation reduction. During these processes, the high needs for zinc can be supplemented externally, generally increasing the rates of the natural processes. Topical zinc delivery involves the pharmacologic optimization of zinc delivery, often mediated by the solubility of the zinc material and interactions within the product matrix.
PMID: 16029676 [PubMed - indexed for MEDLINE]
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People who are ill, typically do not have an appetite, and thus eat poorly.
Economics also drive this negative spiral. Many people of all ages do not
consume quality protein. If they take chronic doses of acid reducing drugs, they also limit zinc absorption, which is dependant on acid. So attention to
this mineral is very important from acne, so serious wound repair (from surgery or pressure sores, or trauma).
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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